Protective Effect of Carvacrol in 6-hydroxydopamine Hemi-parkinsonian Rat Model
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چکیده
Background and Objective: A huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in Parkinson’s disease (PD). Polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalities in an animal model of PD. Materials and Methods: In this study, unilateral intrastriatal 6hydroxydopamine injected rats were daily pretreated with carvacrol (10 mg/kg) started three days before the surgery. Apomorphine-induced rotations and level of stress oxidative markers in the midbrain were assessed after 2 weeks. Results: Carvacrol administration lessened the rotation number in lesioned rats. Also, carvacrol decreased the 6-OHDA-induced malondialdehyde and nitrite level and intensified the antioxidant enzyme catalase, indicative of a protective effect against lipid peroxidation and free radicals synthesis. Conclusion: In summary, carvacrol shows a protective effect against 6-OHDA neurotoxicity, partly through attenuating oxidative stress.
منابع مشابه
Protective Effect of Carvacrol in 6-hydroxydopamine Hemi-parkinsonian Rat Model
Background and Objective: A huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in Parkinson’s disease (PD). Polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalitie...
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متن کاملNeuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
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